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is a thirteen episode Japan anime series created by Takumi Tsukumo and directed by Hiroshi Negishi, with production by Operation EVE and animation production from RADIX.

The series is a science fiction story set in the far future, incorporating aspects of space opera. The character-driven storyline focuses primarily on the psychology of the main character, her social interactions, her inhuman abilities, and the conspiracy surrounding them. The technology is often secondary to this, but it is not ignored; several aspects, including their means of faster-than-light travel, are explained and loosely based on modern physics.

In North America, the television series was produced by ADV Films, aired from 2 July 2003 to 24 September 2003, ran for 13 episodes, and was released in 3 volumes on VHS and DVD.

The series was a hit in Japan, which led to the creation of a sequel, Misaki Chronicles, which also ran for 13 episodes.

Misaki Kureha has not been a contender in any CBUB matches.