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Donna Noble (later Donna Temple-Noble) is a fictional character played by Catherine Tate in the long-running British science fiction television series Doctor Who. A secretary from Chiswick, London, she is a companion of the Tenth Doctor, appearing in one scene at the end of the final episode of the 2006 series, "Doomsday", leading into the programme's second Christmas special, "The Runaway Bride". When the character refused the Doctor's invitation to become a permanent travelling companion, for the programme's third series (2007), the Doctor travelled alongside medical student Martha Jones (Freema Agyeman). However, Donna returned as The Doctor's sole full-time companion for the whole of the fourth series in 2008, and reprised the role once more in the 2009-10 special The End of Time.

Within the series' narrative, Donna begins as an outspoken middle age Londoner, whose view of the universe is small in scope. Although she at first finds alien time traveller the Doctor terrifying, their initial encounter leaves her unsatisfied with her small little world, and she jumps at the chance to travel alongside him when the next opportunity arises. Her very human perspective saves the Doctor's life when they first meet, and persuades him to act more compassionately and make exceptions to the rules in order to save individual lives; in return, Donna becomes a more worldly and heroic individual. From humble beginnings, it is Donna who saves the universe in the fourth series' conclusion, although tragically at the cost of the memories of her travels with the Doctor, leaving her, once again, largely the woman she was before she met him. In a contrast to the Tenth Doctor's prior female companions, who both harboured romantic feelings for him, Donna and the Doctor shared a strictly platonic relationship; the Doctor refers to her as his "best mate".

Donna Noble makes her first appearance, credited as "The Bride", in the closing scenes of 2006 series finale "Doomsday"; she appears in a wedding dress, outraged to be inexplicably aboard the Doctor's TARDIS. The scene was kept a secret until broadcast, filmed with minimal crew, and was a humorous juxtaposition to the sad farewell the Doctor shared with companion Rose (Billie Piper) moments prior. Donna's story is picked up in 2006 Christmas special "The Runaway Bride". Donna is a temporary secretary at H.C. Clements in London, a security firm which, unknown to her, is a front organization for the alien-investigating Torchwood Institute. Her parents are Geoff (Howard Attfield) and Sylvia Noble (Jacqueline King). Donna discovers that she is a pawn in a scheme of the Empress (Sarah Parish) of the alien Racnoss, having been manipulated by her fiancé, Lance (Don Gilet). When the Doctor unleashes his fury upon the Racnoss, Donna snaps him out of it and together, they escape before the Torchwood facility floods. Donna is upset, having lost her job and her fiancé, and declines the Doctor's offer to become his companion, though she advises he find one. Donna does not appear in the 2007 series, but the character Wilfred Mott (Bernard Cribbins) appears in 2007 Christmas special "Voyage of the Damned"; in the 2008 series, he is introduced properly as Donna's grandfather, following the death of actor Howard Attfield.

In series four premiere "Partners in Crime" (2008), Donna has become dissatisfied with regular life and more interested in the bigger picture. When both are investigating the alien connection to Adipose Industries' Miss Foster (Sarah Lancashire), she and the Doctor are re-united, and she joins him in the TARDIS as a regular companion. In "The Fires of Pompeii", Donna shows her compassion when she argues and convinces the Doctor to save a family from the Pompeii eruption of Mount Vesuvius. In "The Doctor's Daughter", it is Donna who names the eponymous character "Jenny" (Georgia Moffett). The episode "Turn Left" features a parallel universe wherein Donna never met the Doctor; consequently, the Doctor died and the world comes to an end much sooner. In finale episodes "The Stolen Earth" and "Journey's End", Donna touches the Doctor's energised severed hand and is imbued with the totality of his knowledge, using which, she is able to stop Davros (Julian Bleach) and his plan to destroy reality. However, because her mind cannot handle the knowledge, the Doctor is forced to wipe her memory of him and hope that they never meet again, lest she remember and her mind "burn up". Donna reappears in the two-part The End of Time (2009–10). When every member of the human race becomes a clone of the Doctor's archnemesis the Master (John Simm), Donna's memories are nearly restored; however, a fail-safe installed by the Doctor protects her. In the story's concluding moments, Donna marries new fiancé Shaun Temple (Karl Collins), becoming Donna Temple-Noble; the Doctor delivers her a winning lottery ticket to ensure her financial future.

Donna Noble has not been a contender in any CBUB matches.