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, addressed as Sojiro Seta in the English-language dubs, is a fictional character from the Rurouni Kenshin universe created by Nobuhiro Watsuki for the series and developed into a media franchise, which consists of a series of manga, anime, OVAs, movies, soundtrack, video game, and other collectible. In the story, he is Shishio Makoto's right hand man. Sōjirō has been favorably popular with the Rurouni Kenshin reader base, placing high in several popularity polls.

Nobuhiro Watsuki has stated that the character design of Sōjirō is loosely based on Okita Sōji, the captain of the first Squad of the Shinsengumi. The name Seta Sōjirō originates from "Okita Sōjirō," the name Okita had in his early life. The specific personality model is from the Okita in Ryōtarō Shiba's novel Shinsengumi Keppuroku ("Record of Shinsengumi Bloodshed"); in that version Okita "lost an important part in his human heart," making him without emotions and "pretty scary." Watsuki reported that some fans did not like the fact that a character modeled on Okita is a villain; Watsuki argued that since Sōjirō is based on the Shinsengumi Keppuroku Okita, the design "works well" and that Sōjirō is "a strong antagonist." Watsuki felt that Sōjirō was more difficult to draw than Watsuki initially anticipated, and that he only accomplished around one fourth of what he imagined the character would appear in his mind. Watsuki had no design model for Sōjirō; Watsuki envisioned Okita as having bangs (fringes) , so to Watsuki it was no surprise that Sōjirō also had bangs. Watsuki gave Sōjirō a "slightly feminized air" so that Sōjirō's smile would "look good" on the character. In Volume 9 Watsuki stated that he wants to properly portray Sōjirō since he is a popular character.

The fact that Sōjirō has no emotions is also based on Shiba's version of Okita Sōji. Watsuki said that this concept became one of the most difficult aspects to reflect in the drawing. Okita died when he was young, but Watsuki decided not to kill Sōjirō in the story in order to atone for the murders he committed, but instead start living on his own instead of having someone make his decisions for him. He hoped to draw him in more of the next chapters but soon thought that would not be possible.

Sōjirō is Shishio's right hand man, a young assassin trained by Shishio himself. Sōjirō is known for his lack of kenki (offensive aura), or, simply, emotion. He possesses no anger and incites no fear in his enemies, other than with his sword. This is reflected in his appearance, as he looks very ordinary and has no distinctive features in either his dress or his face.

Soujiro Seta has not been a contender in any CBUB matches.