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, also known as just , is a fictional character from the comedy manga series Yotsuba&!, as well as the one-shot manga "Try! Try! Try!", both by Kiyohiko Azuma. As the title character of the series and almost every chapter, Yotsuba is usually the focus of each episode; most stories revolve around her meeting, and often childishly misunderstanding, a new concept or activity indicated in the chapter title. She is noted for her childish energy, unusual naiveté, and iconic appearance.

Yotsuba first appeared in a one-shot manga published in 1998 and two webcomics called "Try! Try! Try!", where she appears substantially the same as at the start of Yotsuba&!

Yotsuba is drawn as a small girl with green hair done in four pigtails, giving her somewhat the appearance of her namesake, a . She has a carefree and energetic personality, taking delight in simple matters even as she learns about all manner of things in her daily life. In Japanese, Yotsuba's dialogue is written without kanji, making it seem simpler and more child-like, and in a typeface that gives the impression of speaking with high intensity. Her energy is noted by other characters, especially members of the neighboring Ayase family. Her father says of her carefree nature, "She can find happiness in anything. Nothing in this world can get her down." However, when deeply frightened or upset, she does cry, and she has an unexplained fear of anything resembling a bullseye.

At the start of the series, Yotsuba is shown as having very little knowledge of the world around her, even for a young child. Things such as swings, doorbells, cicadas, and air conditioners all fascinate and confuse her, although she is not perturbed by her ignorance. She occasionally mispronounces new words and creates neologism, such as as a portmanteau of "Yotsuba's Box", and often repeats, in incongruous ways, phrases spoken by adult characters around her. Yotsuba is able to slowly sound out writing in hiragana, and is praised for this by her father's friend Jumbo, but cannot correctly read a clock. She is frequently shown drawing, though she is not as good an artist as she thinks she is, and she is an excellent swimmer.

Yotsuba Koiwai has not been a contender in any CBUB matches.