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The Guild of Calamitous Intent is a fictional organization of supervillain in the Adult Swim program The Venture Bros.. The Guild was first mentioned in the season one episode "Home Insecurity", with its first major appearance being in "The Trial of the Monarch". According to Doc Hammer, the Guild was created specifically to allow the "super scientists" and "supervillains" in the Venture universe to co-exist for the Tag Sale – You're It! episode.

In the Venture Bros. series the Guild of Calamitous Intent is the largest organized labor group representing supervillains. Its direct competitors are The Peril Partnership and the Fraternity of Torment, both of which control less than a tenth of organized havoc to the Guild's overwhelming majority. In the episode Fallen Arches, a promotional video sent to the character Dr. Orpheus states that the Guild was founded in 1910, and it is "the recognized leader in organized havoc". They credit their large numbers to the fact that they offer protection from authorities and benefits such as health and dental insurance to all members, as well as access to henchmen and other technology to help villains commit crimes. In exchange, Guild members are required to follow a code of honor (see " ").

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