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Adhisaya Manithan ( ) is a 1990 Indian Tamil-language science fiction slasher film directed by Velu Prabhakaran. It is a sequel to Naalai Manithan (1989). The film stars Gautami, Ajay Rathnam, Anand, Kuyili, Kovai Sarala and Silk Smitha. It was released on 6 July 1990.

Five years after the incidents of the first film, researcher Charles, the brother of one of the Scientists, finds that John, the psychotic killer, is still alive and informs his friend Ravi, a Police officer to kill him as soon as possible.

Four college students – Kousalya, Urmila, Lynda and Nancy along with their boyfriends Gupta, Majnu, Vivek and Ramani go for vacation to an isolated mansion set aside of the town. They also take their colleague Ganga, a depressed girl, along with them by lying to her that they are going to meet a doctor to treat her medical condition. The mansion looks abandoned and it is shown that there is no human activity nearby.

As the researcher suggested, the psychotic John, who previously murdered a rancher and his wife, roams around the mansion to kill the youngsters. While on a trip, some goons misbehaves with Kousalya, and get beaten up by Gupta. The Goons in revenge enter the mansion to kill Gupta, but were killed by John one by one. In the meantime Charles, after examining the dead bodies of the rancher and his wife gives Ravi some bullets injected with drugs which may stop activities of John.

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